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Safety issues have cropped up among SGLT2 patients, such as a risk of bone fractures and worries about decreased bone density associated with Johnson & Johnsons Invokana
Intriguingly, a first-of-its-kind SGLT2i trial and secondary analysis in patients with HFmrEF and HFpEF showed a 29% reduction in patients' risk of HHF [74, 75], although this effect was diminished in patients with EF 65%
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